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doi: 10.2337/dc11-0291

Introduction Choline is an essential nutrient for humans and acts as a precursor for the neurotransmitter acetylcholine and membrane lipids such as phosphatidylcholine (PC) and sphingomyelin through the Kennedy pathway (1, 2, 3, 4, 5) (Fig 1A)

The SURMOUNT-1 trial showed participants losing up to 22.5% of their body weight on the highest dose, compared to approximately 15-17% with semaglutide in the STEP trials