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In adult clinical trials, severe GI adverse reactions were reported more frequently among patients receiving Wegovy than placebo

In addition to these differences, secretion of GIP and GLP1 and their insulinotropic effects on cells have been shown to differ in patients with type 2 diabetes compared to healthy subjects

GLP-1R regulates brain glucose metabolism The most prominent physiological effect of GLP-1 and GLP-1R is the regulation of insulin secretion in the pancreas to maintain postprandial glucose homeostasis, whereas outside the pancreas, GLP-1 and GLP-1R also regulate feeding and metabolism through the nervous system

Published October 6, 2022.Accessed August 24,2023