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140 It has also been reported that high mechanical loading not only promotes the secretion of inflammatory and pain-related factors of IVD cells, such as TNF-, IL-6, IL-8, IL-17, IFN-, monocyte chemoattractant protein 1 (MCP-1), and NGF, but also upregulates TLR2 and TLR4 expression, indicating that mechanical stress may play important roles in inducing and maintaining discogenic LBP

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Sema exerts anti-fibrotic and anti-hypertrophic effects by attenuating ECM proteins (Fig