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Factors that increase estrogen activity include: Low Sex Hormone Binding Globulin (SHBG), which can be caused by blood sugar dysregulation and higher insulin production, allowing higher free estrogen Xenoestrogen exposure (environmental endocrine disruptors like BPA from plastic) Excess adipose (fat) tissue (aromatase activity converts androgens to estrogen in fat cells) Impaired hepatic estrogen metabolism Chronic Inflammation Fibroid tissue has a distinct inflammatory microenvironment

This is what we call bioavailabilitythe measure of how much of a substance enters your circulation and is able to have an active effect

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Retrieved 5 March 2020