Ipsen DH, Tveden-Nyborg P, Rolin B, Rakipovski G, Beck M, Mortensen LW, Faerk L, Heegaard PM, Moller P, Lykkesfeldt J (2016) High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs
For some numbers, which I think are interesting and just to illustrate, if Semaglutide becomes truly a mega blockbuster, an example of this is Humira by AbbVie, that generated $200 billion in lifetime sales since Humira was approved for 11 different indications across this whole spectrum of inflammatory and autoimmune disorders
In this case, overall assessment (WoE) of the general biological plausibility and of the empirical support of KERs was considered as high for this AOP, as well as essentiality, once for this criterion the first four KEs that trigger the AO are also classified as such
Step 4: DO NOT SHAKE