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Nausea is the most common side effect, particularly during the first few weeks or after a dose increase
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If a patient fails to achieve desired results on tirzepatide monotherapy after adequate dose optimization, the appropriate next stepas supported by clinical guidelinesis to discontinue tirzepatide and switch to a different class of weight-loss medication (such as an orlistat or a future non-GLP-1 agent), not to add semaglutide
A flat abdomen may also look broad when side tissue fills the flanks
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