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Notably, it can also augment the enzymatic action of telomerase, potentially supporting telomere elongation ( 3.2.1.2 Vitamin E Vitamin E is a lipid-soluble antioxidant, primarily located in cell membranes, with its primary role to protect polyunsaturated fatty acids (PUFAs) from lipid peroxidation, which is a significant source of DNA damage, including telomeres ( 3.2.1.3 Polyphenols Polyphenols, widely present in sources such as fruits, vegetables, or tea, exert antioxidant effects by neutralizing oxidizing species

The cleavage enzyme can be selected from Yeast ubiquitin hydrolase (YUH1) and the like

Additionally, the depletion of MnSOD (superoxide dismutase) in RPE cells triggered the Hsp70-linked ubiquitin-dependent cleavage of GPX4, exacerbating ferroptosis of these cells (89)

Birth control pills or other hormonal therapies can sometimes be prescribed as a course of treatment, but it's essential to discuss the benefits and risks with your healthcare provider