Prescription GLP-1 medications such as Wegovy, Ozempic, Zepbound, Mounjaro, Saxenda, Trulicity, and others are regulated medications that require medical supervision (Reference)
Sustained signaling by internalized GLP-1Rs has been reported, but without increasing insulin release 10
In a head-to-head Phase 3b trial published in the New England Journal of Medicine, tirzepatide demonstrated greater weight reduction than semaglutide at 72 weeks in adults with obesity without type 2 diabetes
Notably, the study found that the use of GLP-1 RAs for a duration of 13 years was associated with a heightened risk of all thyroid cancers, presenting an adjusted hazard ratio of 1.58 (95% CI 1.271.95) and an adjusted HR of 1.78 (95% CI 1.043.05), specifically for medullary thyroid cancer