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JAMA Network

C-peptide levels are measured instead of insulin levels because C-peptide can assess a person's own insulin secretion even if they receive insulin injections, and because the liver metabolizes a large and variable amount of insulin secreted into the portal vein but does not metabolize C-peptide, meaning blood C-peptide may be a better measure of portal insulin secretion than insulin itself

EM density map and the model are shown for GLP-1, PF 06882961, OWL-833 and all seven TM helices, and ECLs of the GLP-1R when bound to each agonist