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Small sizes of NLC particles could enhance the close contact of formulation with stratum corneum which amplifies the drug to flux through the skin and due to the presence of solid lipid into it, it also enhances the controlled release of API from the carriers [63,64,65]

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The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma

Those with cirrhosis require specialist hepatology care, including surveillance for hepatocellular carcinoma (six-monthly ultrasound and alpha-fetoprotein) and screening for oesophageal varices (endoscopy)