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Unnisa, A., Greig, N

Prolonged metabolic stress impairs mitophagy and reduces mitochondrial function, as indicated by decreased oxidative phosphorylation, impaired ATP synthesis, and elevated reactive oxygen species (ROS) generation (22)

Simultaneously, weight loss from therapy improves adipose tissue function, allowing healthier HDL particle production and clearance of oxidized LDL from vessel walls

Experimental models demonstrate that restoring glutathione normalizes mitochondrial redox status and improves endothelial and cardiovascular function, supporting a causal role for mitochondrial glutathione depletion in cardiovascular aging (17-18)