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Furthermore, concerns regarding the accumulation of Ag NPs in major organs (e.g., liver, spleen, and kidneys), the generation of reactive oxygen species (ROS), and potential genotoxic effects have led regulatory agencies such as the FDA and EMA to advocate for more stringent standardization protocols and comprehensive toxicity profiling to ensure safety and reproducibility [244]

Subcellular distribution and nrf2/keap1-interacting properties of glutathione S-transferase P in hepatocellular carcinoma