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Elife 6 , e28899 (2017)

Simultaneously, the development of TIND suggests that the rapid improvements in glycemic control often achieved with these agents can paradoxically trigger neuropathic syndromes in some individuals

Physical changes such as fat loss or muscle growth typically take longer to become noticeable

Factors that are considered include, but are not limited to, mechanism of tear (traumatic or degenerative), pattern of the tear, location of the tear, symptoms, age of the patient, and activity level of the patient