This foundational discovery later recognized with the 2024 LaskerDeBakey Clinical Medical Research Award for Habener, Mojsov, and Lotte Bjerre Knudsen laid the foundation for an entirely new class of GLP-1 medications.[1] Gut releases natural GLP-1 that is destroyed in the bloodstream within about two minutes by the enzyme DPP-4 that is a widely distributed integral membrane protein that is expressed in the intestine, kidney, vascular endothelium, liver pancreas, glandular epithelial cells, and immune system cells.[17] Hence, DPP-4 inhibitors are a successful class of anti-hyperglycaemic agents used to treat type 2 diabetes (T2DM) via protecting GLP-1
Jeter MD, Zhu G, Jin J, Liao Z, Zhang Z, Ajani J, Swisher S , Chang JY, Guerrero T, Stevens CW, Vaporciyan A, Komaki R
Can BPC-157 Also Help with Gut Health
Persistent Nausea, vomiting or diarrhea can cause fluid loss and acute kidney injury in susceptible patients