A caloric deficit in this range is considered as extreme calorie restriction, which puts individuals at risk for malnutrition, fatigue, decreased energy, impaired immune functioning and nutrient deficiencies
An online search utilizing the PubMed search engine was carried out using the MeSH terms Diabetes Mellitus, Hyperglycemia, Diabetes Complications, Hypoglycemic Agents, Glucagon-Like Peptide-1 Receptor Agonists, Glycoside Hydrolase Inhibitors, Acarbose, Metformin, Dipeptidyl-Peptidase IV Inhibitors, Sodium-Glucose Transporter 2 Inhibitors, Drug-Related Side Effects and Adverse Reactions, Gastrointestinal Diseases, Gastroparesis, Gastric Emptying, Dysbiosis, Gastrointestinal Microbiome, Microbiota, Constipation, Diarrhea, Nausea, Vomiting, Gastrointestinal Agents
Environ Toxicol Pharmacol (2008) 25:38692
Medication adherence for GLP-1s may include consistency to the prescribed dosage, timing, and frequency of GLP-1s