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2013;98(2):E291E300.

For the open-label treatment extension period analysis, only the efficacy estimand was used due to the lack of a true placebo group

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How to increase GLP-1 naturally While prescription medications offer the most powerful way to boost GLP-1 activity, there are several evidence-based strategies for increasing GLP-1 naturally: Dietary fibre: Foods rich in fibre, like beans, pulses, whole grains, nuts, and seeds, help feed beneficial gut bacteria that encourage natural GLP-1 production