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Additional hypothalamic pathways contributing to hunger involve the lateral hypothalamus and the parabrachial nucleus via calcitonin gene-related peptide (CGRP) neurons.44,45 With food entry into the stomach, afferents in the vagus nerve signals to the nucleus tractus solitarius (NTS), and reflexively induces gastric accommodation.46 This relaxation (Figure 2B) results in distention of the stomach and vagal signals fire to induce the sensation of fullness and terminate the meal

[15] [16] This is especially relevant for immediate-release exenatide, where timing with other oral medicines may need adjustment

No, sweating is not listed as a common or recognized side effect in FDA prescribing information for tirzepatide (Mounjaro or Zepbound)

4C), and more mucosal ulceration score 3 (Fig