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They release various factors including TNF-, IL-1, IL-6, glutamate, and NO, contributing to oligodendrocyte injury and axonal degeneration

In controlled laboratory research models, IGF-1 LR3 binds to the insulin-like growth factor-1 receptor (IGF-1R), initiating downstream signaling cascades commonly associated with PI3K/Akt and MAPK/ERK pathway activation under defined experimental conditions