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People tracking their progress with tools like the semaglutide dosage calculator should know that proper dosing correlates with these metabolic improvements

This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity. Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications.

Later in 2022, the FDA granted tirzepetide fast track designation for overweight and obesity in adults.6 To date, tirzepetide hasnt been FDA approved for weight loss (see table Current FDA-Approved Mono and Dual Agonists for details about weight management medications)