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The article introduces key regulatory factors and mechanisms of ferroptosis in kidney diseases, as well as important concepts and major open questions in ferroptosis and related natural compounds

In the present study, we enrolled 554 patients with CKD stages 35 who had used or not used NAC for three years, and we collected data for renal functionserum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) every 6 months for three years to explore whether NAC use could improve renal function and reduce the risks associated with hemodialysis (HD)