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Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study

Oishi Y, Taniguchi K, Matsumoto H, Ishihara A, Ohira Y, Roy RR

While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

Muscle supports metabolic rate, meaning the more lean tissue maintained, the more calories the body burns at rest