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Glial innate immunity in neurodegenerative diseases Early studies established that cytosolic DNA can elicit innate immune responses and innate inflammation, inducing type I interferons (IFNs), yet the molecular mechanism underlying this sensing remained unresolved (Seth et al., 2006)

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In addition, increasing STAT3 from activated JAK/STAT signaling pathway might be involved in the apoptosis of cell through PTEN, which inhibits Akt cascade, resulting in exacerbated hyperglycemia 136 (Fig