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The impact of TXNIP on ferroptosis seems to be manifold, as it downregulates SLC7A11 and GPX4 levels [108,122] , increases the labile iron pool via NCOA4-mediated ferritinophagy [123,124] , and disrupts GSH synthesis (Figure 3) [112]

Jegatheesan P, Beutheu S, Ventura G, Sarfati G, Nubret E, Kapel N, Waligora-Dupriet AJ, Bergheim I, Cynober L, De-Bandt JP (2016) Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease