why glp 1 not working 7 Reasons You Aren't Losing Weight on Weight Loss Drugs Type 1s can't get GLP-1s?

Compounded medications are not FDA-approved, are not generics, and do not undergo the same FDA premarket review for safety, effectiveness, quality, labeling, and manufacturing as brand products

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Zhou W, Nielsen JB, Fritsche LG, Dey R, Gabrielsen ME, Wolford BN, et al

As discussed above, endogenous GLP-1 is rapidly degraded by DPP-4, whereby it loses its insulinotropic activity, and preventing this degradation results in increased intact GLP-1 levels, improved pancreatic islet responses (enhanced insulin and suppressed glucagon levels) and beneficial effects on glucose homeostasis