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HepaRG cells (8000 cells/25 L/well) or PHHs (Hu8163, 17,500 cells/25 L/well) were seeded in collagen I-coated 384-well white flat-bottom plates (Corning, catalog: 354665)

Patients in major metropolitan areas including Los Angeles, New York, Houston, and Miami, where concierge medicine, functional medicine, and sports medicine clinics frequently offer cutting-edge supplements and unapproved therapies, are most likely to be targeted with marketing for these compounds once they become more accessible through regulated channels

Only 11.2% of participants stopped the trial due to side effects, and the discontinuation rate dropped significantly after week 24, suggesting those who make it through the early phase generally tolerate it well long-term

TB-500 corresponds to the active region of Thymosin Beta-4, a naturally occurring 43-amino-acid protein involved in regulating the actin cytoskeleton