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Clinical trial data shows increased incidence of biliary disease, likely related to rapid weight loss and altered bile composition during metabolic changes

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Specifically, TMPRSS2 processes the SARS-CoV-2 S-protein and enables the viral entry into host cells within 100-fold during infections and clinical conditions such as sepsis, renal ischemia-reperfusion injury and acute lung injury (ALI) 464

Eight weeks of treatment increased treadmill endurance, improved fatigue resistance, and even increased muscle mass compared to untreated controls