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UA administration to mice before the onset of clinical EAE may protect the integrity of the BBB from changes in ONOO -induced permeability, thus minimizing the infiltration of inflammatory cells and other pathogenic cells and factors and the resulting pathology [193](Fig
Why it matters: In Eli Lillys Phase 2 trial, the highest dose produced 24.2% mean weight loss at 48 weeks the largest reduction ever reported for an anti-obesity drug at this stage
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