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They help regulate key functions like metabolism, healing, energy production, and hormonal communication

Further, despite the increase in GFR, bardoxolone methyl seems to lead to an increase in urinary protein excretion [57,59], raising the question and concern whether this could be related to the undesirable glomerular hyperfiltration or increased intraglomerular pressure that contributes to kidney disease progression long term [61]

[9] Majority of the patients experience normal transit time and stool frequency

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