switching between glp-1 agonists Mechanisms of action of RA and GLP-1/GIP dual agonists. ↑: Switching between GLP‐1 receptor agonists

Abbreviations 1-RM: One-repetition maximum ALT: Alanine aminotransferase AST: Aspartate aminotransferase ATP: Adenosine triphosphate cGMP: Cyclic guanosine monophosphate CK: Creatine kinase GGT: Gamma glutamyl transferase GSH: Glutathione GSNO: S -nitrosoglutathione LDH: Lactate dehydrogenase MCH: Mean corpuscular hemoglobin MCHC: Mean corpuscular hemoglobin concentration MCV: Mean corpuscular volume MPS: Muscle protein synthesis NOS: Nitric oxide synthase PI3K: Phosphoinositide 3-kinase RDW: Red blood cell distribution width RT: Resistance training SEM: Standard error of the mean References Wijnands KAP, Castermans TMR, Hommen MPJ, Meesters DM, Poeze M

For each peptide, we performed also ITC and fitted a 1:1 binding model to the thermogram (Fig

4-6 , 4

This finding supported that oxidative damage and protein nitration are involved in the pathogenesis of MC