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Given the established role of FXR activation in suppressing lipid peroxidation and the critical importance of granulosa cell integrity for follicular development, BAs may represent important endogenous regulators of ovarian function in PCOS

Bioorg Med Chem

Conclusion and Outlooks Accordingly, available data indicate that ROS detoxification pathways are not present to the extent they might remove all ROS from the cellular environment, but that there is a level of coordination between the processes which generate ROS and those which remove them, therefore, maintaining the optimal amount of ROS within the cellular environment

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