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The sensation of fullness from water is mechanically mediated, not hormonally driven through incretin pathways

The EMA and FDA have not identified a causal relationship but retain the label warning because the biological plausibility (pancreatic ductal cell GLP-1 receptor expression) has not been fully excluded

Their weight loss was accompanied by significant reductions in systolic and diastolic blood pressure, triglyceride levels, and glycosylated hemoglobin