This work was supported by the National Health and Medical Research Council (NHMRC) of Australia, through grants APP1103689 and APP1122484 to LEW, DAS and HAH, APP1139763 to RBG, LEW and KAW, a Career Development Fellowship to LEW (APP1127821) and Senior Research and Investigator Fellowships to RBG (APP1117538 and APP2009940)
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12, 16, 18 A high degree of synergistic enhancement of L-PAM cytotoxicity in the presence of BSO was observed in multidrug-resistant neuroblastoma cell lines, including those that were established at relapse after myeloablative therapy with L-PAM and lines highly resistant to L-PAM due to loss of p53 function, especially at concentrations of L-PAM that were myeloablative
The combination allows researchers to examine complementary pathways involved in musculoskeletal and connective tissue repair models
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