Think of it as your pets emergency alarm system when their body spots something it thinks is dangerous, such as pollen, dust, mold, or certain foods, histamine gets released as a first line of defense
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Instead it is required via dietary intake, however for some this either does not happen due to malabsorption, poor intake of B12 rich foods, or other genetic/biological factors (including coeliac)
Besides, when we consider the general wound principles in tissue damage as a dynamic equilibrium between negative and positive events (i.e., necrosis and possibly pus formation vs