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Stay hydrated aggressively air travel is profoundly dehydrating, which compounds GLP-1's effects on constipation

What we know: The same total amount reaches your bloodstream - Clinical trial data confirmed equivalent overall absorption (AUC and Cmax) across all three sites Yet reported side effect rates differed substantially - Thigh showed roughly half the nausea rate of abdomen despite identical systemic exposure Possible explanations include differences in absorption rate (even if total absorption is equal), local tissue effects at the injection site, or simply statistical variation in a relatively small study

(2024) 30:S3954

Patients with a history of tirzepatide use prior to the index date or a documented diagnosis of malignant neoplasms were excluded from the analysis