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In two studies examining the 6-month effects of semaglutide, patients with metabolic dysfunction-associated steatotic liver diseases (MASLD) and showed reduced skeletal muscle steatosis with preservation of muscle mass [86], whereas in patients with MASLD and human immunodeficiency virus, semaglutide led to a 9.3% decrease in psoas muscle volume with no change in muscle fat fraction [87]
Gastrointestinal distress is a commonly reported side effect of GLP-1s, impacting roughly 40% to 70% of patients
E., Ostrominski J
Another subcutaneous injectable version (WEGOVY) is approved for the same indication of obesity or overweight with at least one weight-related comorbidity, in combination with diet and exercise [31,32,33]
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