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Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide

It interacts with enzymes such as neutral endopeptidase and aminopeptidase N, which influence peptide metabolism in tissues

Furthermore, among all treatment groups, the BEAGA/ApoE-PDHD@ILD & R848 nanodrug led to the highest up-regulation of tumor necrosis factor- (TNF- ) and interferon- (IFN- ) (Fig

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