Briefly, when muscle is injured, overused, or mechanically stretched, satellite cells are activated to enter the cell cycle through a cascade of events including nitric oxide (NO) radical-dependent release of the active form of HGF (a hetero-dimer of - and -chains) from its extracellular tethering and the subsequent presentation of HGF to the cell-membrane signaling receptor c-met, followed by the sequence of steps including proliferation to produce myoblast progeny, differentiation, and fusion with existing muscle fibers and/or to form new fibers 18,19,20,21,22, 31
However, translation into human use has historically faced diminished clinical utility due to compound instability in vivo , emergence of adaptive resistance during exposure, or side-effects accompanying treatment (Ji and Miller, 2012
doi: 10.1038/s41588-020-00739-1 19 LarkinJAsciertoPADrenoBAtkinsonVLiszkayGMaioMet al
One of the most popular skin treatment methods using injections involves the use of "Glutathione." This process utilizes IV infusion as part of the skin brightening treatment