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Some medical conditions and symptoms that may predispose someone to adverse effects from tadalafil include: Heart problems like heart failure or a previous heart attack Angina or chest pain Irregular heartbeats High or low blood pressure Retinitis pigmentosa (a rare genetic eye disease) Pulmonary hypertension Stroke Liver disease Kidney disease Severe vision loss Stomach ulcers Bleeding problems Deformed penis shape or Peyronies disease Experience with erections lasting more than 4 hours Blood cell disorders like sickle cell anemia, multiple myeloma, or leukemia Tadalafil can generally be taken with other medications unless there is a known interaction between the two drugs

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