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Furthermore, in the former group the improvement of lipid fractions has been achieved by reducing the CAB dose ( PRL may have a role also in intrahepatic lipid storage since circulating PRL has been demonstrated to be lower in patients with non-alcoholic fatty liver disease (NAFLD) compared to healthy controls ( Future challenges HomeoFIT-PRL: Proposal of a new nosological entity Given the evidence of PRL as a metabolic hormone, recently a new classification of PRL levels has been proposed, also introducing the novel concept of homeostatic functionally increased transient prolactinemia (HomeoFIT-PRL, 11)

263,272 Considerations in women Women of reproductive age taking a GLP-1 receptor agonist or tirzepatide should be advised to use contraception concurrently due to potential safety concerns associated with taking these pharmacotherapies in pregnancy (as shown in animal studies)

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