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Therefore, MVA pathway inhibitors (statins) could block the maturation of Sec-tRNA, subsequently affecting GPX4 synthesis and inducing ferroptosis ( 2.2 The iron metabolism axis Iron is an essential trace element in the human body, mainly in the form of divalent iron (Fe 2+ ) and trivalent iron (Fe 3+ )

Typical oral doses range from 5001500 mg daily in divided doses to account for this limitation