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doi: 10.3389/fphar.2021.622498 Received 28 October 2020 Accepted 11 June 2021 Published 24 June 2021 Volume 12 - 2021 Edited by Uraiwan Panich, Mahidol University, Thailand Reviewed by Mingjiang Yao, Xiyuan Hospital, China Rodrigo Castaneda, Universidad de San Carlos de Guatemala, Guatemala Updates Copyright 2021 Tian, Huang, Wu, Huang, Ko, Zhu and Chen
In the cytoplasm, a destruction complex comprising adenomatous polyposis coli (APC), AXIN, casein kinase 1 (CK1) and glycogen synthase kinase 3 protein (GSK3 protein) captures -catenin by phosphorylating CK1 and GSK3, thus activating the process of -catenin degradation
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