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In Italia semaglutide (Ozempic) rimborsato dal Sistema Sanitario Nazionale (SSN) solo per il trattamento di adulti affetti da diabete mellito di tipo 2 non adeguatamente controllato, in aggiunta alla dieta e allesercizio fisico: a) come monoterapia, quando luso di metformina considerato inappropriato a causa di intolleranza o controindicazioni

7 The major pathologies in VCI are focal, multifocal or diffuse white matter ischemic lesions involving various brain regions, with deafferentation of frontal and limbic cortical structures and interruption of basal ganglia, thalamus, white matter and other sub-frontal areas

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