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Shaking creates shear forces that can physically tear the delicate peptide structures apart

These fluctuations don't invalidate the 28-day window, but they do mean that a vial stored in a standard home refrigerator is experiencing slightly accelerated degradation compared to a pharmaceutical-grade cold storage unit

Biochem Biophys Res Commun 341:100716 Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB (2013) Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial