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Studies in rats and mice show that melatonin has toxic effects if given at extremely high doses (more than 400 mg/kg), but this is tens of thousands of times more than the recommended dose for treating sleep disorders, which varies between 2-10 mg

Additionally, a higher proportion of type III mitochondria, characterized by irregular cristae and evident mitochondrial damage, has been observed in ectopic stromal cells compared with in eutopic cells (37)

When to Seek Medical Advice You should consult a pharmacist or GP if you: Feel cold even when dressed appropriately indoors Have dizziness, low blood pressure , or fatigue See signs of anaemia (pale skin, shortness of breath) Notice irregular or missed periods Were here to help you stay on track with your health goals safely