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Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven

Rotating injection sites systematicallysuch as alternating between abdomen, outer thigh, and upper arm, or using different spots on the same regionprevents repeated trauma to the same tissue and eliminates the risk of lipohypertrophy, a complication that can affect absorption and treatment consistency