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Retatrutide adds glucagon receptor agonism as a third mechanism, which research suggests contributes additional effects on energy expenditure and hepatic fat reduction beyond what dual agonists achieve

The Science: How BPC-157 Works Mechanism 1: Angiogenesis (Blood Vessel Growth) BPC-157's primary mechanism appears to be stimulating new blood vessel formation: Upregulates VEGF (Vascular Endothelial Growth Factor) Enhances growth factor production at injury sites Improves blood flow to healing tissue Better nutrition and oxygen delivery to repair mechanisms This is particularly important for tendon recovery because improved vascularization directly correlates with faster healing

JCI Insight 3, 23793708

Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV