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In addition, transcript abundance of the major murine -adrenergic receptor Adrb3 was markedly induced in isolated eWAT adipocytes from HFD-IF-KO mice (Fig

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Experiments ex vivo have shown that vinpocetine acts as a selective inhibitor of Ca 2+ /calmodulin-dependent cyclic nucleotide phosphodiesterase type I [21,108], a potent blocker of voltage-gated sodium channels [109,110], inhibits platelet aggregation, reduces blood viscosity, vasodilates cerebral arteries, and increases cerebral blood flow [111]