Andrew Huberman mentions that while NAD+ precursor supplements, such as NMN, show promise for improving mitochondrial function and energy, their efficacy varies, and more human studies are needed
[DOI] [PubMed] [Google Scholar] 111.Frontzek K., Bardelli M., Senatore A., Henzi A., Reimann R.R., Bedir S., Marino M., Hussain R., Jurt S., Meisl G., et al
In general, B12 treatment for a minimum of 2 months improves signs and symptoms in all patients with SCD, while Rombergs sign and mild sensory disturbances in the toes and fingers may persist in some patients after several weeks or months of B12 therapy [7,89]
In contrast, oral supplements may have lower absorption rates due to the digestive process