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Moreover, quercetin and its metabolites have been shown in vitro to exert weak to moderate inhibitory effects on key drug-metabolizing enzymes, including cytochrome P450 isoforms CYP3A4 and CYP2C19, as well as several major drug transporters (Mohos et al., 2020)

Manly, J

Metabolic States and Conditions Requiring Caution Patients with G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency) face increased risk of hemolytic anemia when taking glutathione supplements

However, activation of caspase-3 was not essential for the execution of apoptosis-like cell death of RBCs, resulting in the hypothesis that caspases were required for appropriate erythropoiesis [23]