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doi: 10.1016/j.seizure.2022.11.007 61 IkomaYSasakiDMatsuiK

elegans provide a foundational understanding of the metabolic implications of BBOX1 variants, direct translation of this data to human conditions warrants caution

47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG